WELL, first you have to understand what your computer is telling you with that message.
1. It's telling you that on the drive that you have told your Bios to use as your boot drive, its not finding the boot sector. Or, the Bios can't find the drive at all.
2. See iten #1.
So why is it not seeing a boot sector? Having a floppy disk in the FD that does not contain boot information could be the cause of the problem. Make sure there is NO disk in any drive, floppy or CD.
Then Look at your bios by pressing Del or the appropritate key while you system is booting up, from a cold start.
If the time and date are wrong in the first Bios screen, that's a dead givaway that your CMOS battery had failed. They are only spec'd for about four years of use.
They actually can fail at any time. Replacing the CMOS battery is usually pretty easy and the batteries (CR-2032) can be had at any drug store, or discount store, or Radio Shack.
So the bottom line is,,,,,
If your removable drives are empty of disks and your Bios is working and set to boot from your HD, then you can be pretty well assured that the problem lies in the drive itself.
tubut,
you gave us NO information about your sytem so going any further in trying to troubleshoot your problem is fruitless.