Is there any good ones for Vista?

I tried this on Monday and it seemed to work fine.
It does do a reg clean up,plus other things.
Windows Live™ OneCare

Yamicsoft's Vista Manger having Registry Cleaner.

Vista Manger

Is that a good program. Vista Manager?

Working like a charm having more option to customize Windows Vista, even I m using now.

CCleaner and Ace Utilities/System Tuneup are both good

yep i do agree bigtime that vista manager is very good and useful tool with plenty of additional stuff thats handy too

Good enough to buy it or you both still in your trial period ;-). I prefer freeware: certain software is not worth buying condsidering the freeware alternatives. You just need to know where to look and accept, that it might not fulfil all your needs. You may need to accept this or find an additional freeware program and indeed otherwise buy it.