In order to do so, I will need to install and run .NET Framework/Mono? under Wine for nLite to work correctly.
I'll be asking/searching WineHQ and Mono forums/database too.
But has anyone got these programs to work?

Be useful to goto another unattended site with help of writing answer files manually to save effort getting microsoft's setupmgr.exe deployment wizard from support tools to run.

The Windows 2000 source will be transferred to wine's CDrive. Once the process is complete will run under QEMU. As my system is slow
I've heard QEMU can be accelerated to native speeds.

Then again, I mainly need to run Barca for Email and PIM, which Fred Vorck recommends, because I don't know if Linux email programs can import the format; aswell Wine can provide full Internet access for Windows applications. Barca does install, but cannot register serial number or download email.

If anyone has any past experiences this will begin the research. Much appreciated.

If you're planning to run windows on qemu eventually, why not do that bit first? Seems easier...
I'd try virtualbox if qemu is too slow.