While it should be intelligently assumed that removing this might cause a problem since XP x64 was developed directly for AMD x64 CPU's, I wouldn't have written that if I was just guessing. No, what happens is you end up with at least one bang in device manager for the missing driver for your Intel CPU. I've verified this with both a QX6700 and a couple quad xeons. I have zero idea if this will give you a performance detriment or if it's simply a minor annoyance. If you remove AMD CPU, your Intel CPU won't have a driver in Windows. Therefore, rationally, that feature should have a warning to the user that this might be the case.