Double check the list at the top.
After that, I'd only suggest even considering the ones that say "Security", and only if they're well-documented. Always remember, it's Microsoft's programmers we're talking about. These are the same folks who brought us Windows 10 and who are working to shoehorn malware in via Windows Update. They are not to be implicitly trusted!
Consider Woody Leonhard's advice here: http://www.askwoody.com/
MS-DEFCON 2: Patch reliability is unclear. Unless you have an immediate, pressing need to install a specific patch, don't do it.