I do mine the following when using RunonceEX
1. I got a ".iss" file from one of the threads here at MSFN. I dont have the name of the person who created that "iss" script and hence not able to give credit to him/her.
2. first install the application in a test system or vitual machine and export your registration information from this location in the registry
HKEY_LOCAL_MACHINE\SOFTWARE\Macromedia\Dreamweaver\7\Registration
make a reg file of your registration from the above location.
3. Be sure to change the default browser in the taskkill statement, as dreamweaver setup launches the dreamweaver help in it and waits for you to close it.
REM "BE SURE TO CHANGE THE TASKKILL PARAMETER TO THE DEFAULT BROWSER"
REG ADD %KEY%\045 /V 1 /D "%CDROM%\software\applications\dwvrmx7\setup.exe -s -f2\"setup.iss\" " /f
REG ADD %KEY%\045 /V 2 /D "taskkill /F /im FIREFOX.EXE" /f
REG ADD %KEY%\045 /V 3 /D "REGEDIT /S %CDROM%\software\Applications\dwvrmx7\reginfo.reg" /f