I created an HFSLIP, FDV fileset (i.e., no IE, no OE, etc.) with languages and drivers nLited out. This build also removed DTC.
Here's what I was able to install and run:
1. Office 2003 (Word, Excel, Powerpoint) - obviously no Outlook b/c OE is out
2. 7 Zip
3. Acronis True Image 9
5. Open-source Windows Media, Real and QuickTime alternatives plus codecs
7. EasyCleaner2 (free and good registry cleaner)
8. Firefox 1.07
9. Thunderbird 1.07
12. nod32 anti-virus
13. O&O Defrag
14. Sygate Personal Firewall
15. Unclean 2
17. Nero 18.104.22.168
18. TimeMatters (practice management software)
Here's what I was able to install but not run:
1. QuickBooks 2004 (said I needed IE6 to run but installed fine) - I ran IEPatcher on it, didn't work.
Here's what I was not even able to install
1. WordPerfect (supposedly needs Windows Scripting Host)
2. Adobe Acrobat 7 - said I needed IE5.5 or higher
3. PaperPort Pro 9 - said I neede IE4 or higher
In conclusion, I don't think you really need DTC for anything unless you're doing databasing work. I'm gonna make an FDV'd fileset that doesn't have either DTC or COM (but will have Windows Scripting Host) to see if COM makes a difference or not.
Unfortunately, on my main computer it looks like I'll have to leave IE in there since I need Quickbooks, Acrobat 7 and PaperPort 9. On my old laptop which I take around for travel, I'll install modified FDV Win2k.